Cationic bacteriochlorophyll derivatives and uses thereof

Details Cationic bacteriochlorophyll derivatives and uses thereof Cationic bacteriochlorophyll derivatives and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 487/22 (2006.01) A61K 41/00 (2006.01) A61K 31/409 (2006.01)

Patent

CA 2569675

The invention provides cationic tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one positively charged group and/or at least one basic group that is converted to a positively charged group under physiological conditions, preferably Bchls having an onium group derived from a N-containing aliphatic or heterocyclic radical such as ammonium, guanidinium, imidazolium, pyridinium, and the like or a phosphonium, arsonium, oxonium, sulfonium, selenonium, telluronium, stibonium, or bismuthonium group, or a basic group that is converted to such onium groups under physiological conditions, said groups being bound to one or more of the positions 173, 133 and 32 of the Bchl molecule by ester or amide bond. The Bchls are useful for photodynamic therapy and diagnosis.

L'invention concerne des dérivés de bactériochlorophylles tétracycliques et pentacycliques cationiques (Bchl) contenant au moins un groupe chargé positivement et/ou au moins un groupe basique qui est converti en un groupe chargé positivement lorsqu'il est exposé aux conditions physiologiques, et de préférence des Bchl possédant un groupe onium dérivé d'un radical aliphatique ou hétérocyclique contenant du N, tel que l'ammonium, le guanidium, l'imidazolium, le pyridinium etc., ou un groupe phosphonium, arsonium, oxonium, sulfonium, sélénonium, telluronium, stibonium, ou bismuthonium, ou un groupe basique qui est converti en de tels groupes onium dans des conditions physiologiques, lesdits groupes étant liés à une ou plusieurs des positions 173, 133 et 32 de la molécule Bchl par une liaison ester ou amide. Ces Bchl sont utiles pour les traitements et les diagnostics photodynamiques.

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