Cationic cardiolipin analogs and use thereof

Details Cationic cardiolipin analogs and use thereof Cationic cardiolipin analogs and use thereof

C - Chemistry, Metallurgy

07

C

C07C 217/04 (2006.01) A61K 47/18 (2006.01) A61K 47/24 (2006.01) C07C 219/04 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2501990

The invention provides cationic cardiolipin compounds, and methods for synthesizing and using them in liposomal formulation, gene transfection, etc. In particular, the invention provides liposomes comprising cationic cardiolipin analog, pharmaceutical compositions comprising cationic cardiolipin analogs, and methods of using such liposomes and compositions, in delivering active pharmaceutical agents to treat human and animal diseases and/or in diagnostic assays.

L'invention concerne des composés de cardiolipine cationiques et des procédés de synthèse et d'utilisation de ces composés dans des formulations liposomales, la transfection génétique etc. L'invention concerne en particulier des liposomes contenant des analogues de cardiolipine cationiques, des compositions contenant des analogues de cardiolipine cationiques, et des procédés d'utilisation de tels liposomes et compositions dans l'administration d'agents pharmaceutiques destinés au traitement de maladies humaines et animales et/ou dans des dosages diagnostiques.

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