C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/56 (2006.01)
Patent
CA 2585775
The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.
L'invention porte sur des céramides cationiques, leurs analogues dihydro et aromatiques, et leurs dérivés dont un groupe pyridinium. L'invention porte également sur les procédés de préparation de ces céramides comprenant un groupe pyridinium, et sur leur utilisation pour le traitement ou la prévention de maladies associées à la surprolifération et à la transduction du signal sphingolipidique telles que le cancer, les inflammations, et les sténoses. Ces composés s'avèrent également utiles en tant qu'agents mitochondritropiques localisé dans des mitochondries porteuses de charges chimiques telles que des drogues, ou des molécules de signalisation telles que des fluorophores en vue de l'examen des structures et fonctions des organelles.
Bielawska Alicja
Hannun Yusuf
Obeid Lina
Ogretmen Besim
Szulc Zdzislaw
Musc Foundation For Research Development
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
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