A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/24 (2006.01) A61K 49/00 (2006.01)
Patent
CA 2283327
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
La présente invention permet de cibler sélectivement des cellules endothéliales angiogéniques au moyen de complexes lipide/ADN ou de liposomes cationiques contenant une substance qui influe sur les cellules ciblées en inhibant ou en facilitant leur croissance. On peut déterminer précisément un site d'angiogenèse en administrant des liposomes cationiques contenant un marqueur décelable. Les complexes de la présente invention peuvent comprendre des nucléotides de synthèse contenant des promoteurs qui sont activés de manière sélective et exclusive dans l'environnement d'une cellule endothéliale angiogénique.
Baluk Peter
Gavin Thurston O.
Mcdonald Donald M.
Mclean John
Fetherstonhaugh & Co.
The Regents Of The University Of California
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