Cationic lipids for gene therapy

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 279/14 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/22 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07C 233/01 (2006.01) C07C 237/06 (2006.01) C07C 279/22 (2006.01) C07C 279/24 (2006.01) C07C 317/50 (2006.01) C07C 323/60 (2006.01) C07D 233/30 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2217550

This invention provides novel cationic lipids, particularly guanidino lipids, and methods for their preparation. Also provided are polyanionic-lipid complexes comprising the lipids of the invention, their preparation and use to deliver biologically active substances, particularly nucleic acids to cells.

Dévoilement de lipides cationiques nouveaux, en particulier de guanidino-lipides, et de leurs méthodes de préparation. On divulgue également des complexes de lipides polyanioniques comprenant les lipides de l'invention, leur préparation et leur utilisation pour transporter des substances biologiquement actives, en particulier des acides nucléiques, jusqu'aux cellules.

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