A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 31/337 (2006.01)
Patent
CA 2383412
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
Des cellules endothéliales angiogéniques sont ciblées de manière sélective avec des complexes de lipides/d'ADN ou des liposomes cationiques renfermant une substance qui influence les cellules ciblées et inhibe ou promeut leur croissance. On peut localiser de manière précise un site d'angiogenèse par administration de liposomes cationiques contenant une étiquette décelable. Les complexes peuvent comprendre des constructions de nucléotides qui renferment des promoteurs sélectivement et exclusivement activés dans l'environnement d'une cellule endothéliale angiogénique.
Gavin Thurston O.
Mcdonald Donald M.
Mclean John W.
Fetherstonhaugh & Co.
The Regents Of The University Of California
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