Cationic sirnas, synthesis and use for interfering rna

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2713075

The invention relates to cationic siRNAs, characterized in that they are double-stranded RNA fragments, grafted to the ends of which are oligocations, the number of cationic charges grafted being comparable to or greater than that of the anionic charges carried by the internucleoside phosphates of the RNA strands.

L'invention se rapporte à des siRNA cationiques, caractérisés en ce qu'il s'agit de fragments d'ARN double brin, aux extrémités desquels sont greffés des oligocations, le nombre de charges cationiques greffées étant comparable ou supérieur à celui des charges anioniques portées par les phosphates internucléosidiques des brins d'ARN.

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