C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/87 (2006.01)
Patent
CA 2549736
A method of treating a Myobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.
La présente invention se rapporte à une méthode de traitement d'une infection appelée Myobacterium tuberculosis chez un sujet nécessitant un tel traitement, ladite méthode consistant à administrer au sujet une quantité efficace d'un composé benzofurane substitué cationique. Les méthodes de traitement d'infections microbiennes, y compris les infections d'origine protozoaire, telles que Leishmania donovani, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, et Plasmodium falciparum, et les infections d'origine fongique telles que Candida albicans, Aspergillus fumigatus, et Cryptococcus neoformans, chez un sujet nécessitant un tel traitement consistent à administrer au sujet une quantité efficace d'un composé benzofurane substitué cationique. Cette invention concerne également les méthodes de synthèse des nouveaux composés benzofurane substitués cationiques et les nouveaux composés eux-mêmes.
Bakunov Stanislav
Bakunova Svetlana
Franzblau Scott Gary
Tidwell Richard R.
Werbovetz Karl
Franzblau Scott Gary
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
The University Of North Carolina At Chapel Hill
Werbovetz Karl
LandOfFree
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