Cationic virosomes as transfer system for genetic material

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2253561

The present invention relates to a positively charged virosome for efficient delivery of genetic material to resting or proliferating mammalian cells in vitro and in vivo. The virosome membrane contains cationic and/or polycationic lipids, at least one viral fusion peptide and preferably at least one cell- specific marker, advantageously selected from the group consisting of monoclonal antibodies, antibody fragments F(ab')2 and Fab', cytokines, and growth factors, for a selective detection and binding of target cells. The invention further relates to a method for the manufacture of the novel virosomes and to applications thereof, particularly for the manufacture of pharmaceutical compositions to treat cancer or leukemia.

La présente invention concerne un virosome à charge positive, destiné à un apport efficace, in vitro et in vivo, de matériel génétique à des cellules mammifères au repos ou proliférantes. La membrane du virosome contient des lipides cationiques et/ou polycationiques, au moins un peptide de fusion viral et, de préférence, au moins un marqueur spécifique des cellules, avantageusement choisi dans le groupe constitué par des anticorps monoclonaux, des fragments F(ab')¿2? et Fab' d'anticorps, des cytokines et des facteurs de croissance, aux fins de détection sélective de cellules cibles et de fixation sélective sur celles-ci. L'invention concerne encore un procédé de préparation de nouveaux virosomes, ainsi que des utilisations de ceux-ci, notamment pour la fabrication de compositions pharmaceutiques destinées au traitement du cancer ou de la leucémie.

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