A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/139, 167/37
A61K 49/00 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) G01N 33/531 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1309340
CATIONIZED ANTIBODIES FOR DELIVERY THROUGH THE BLOOD BRAIN BARRIER Abstract of the Disclosure The rate of trancytosis of antibodies across the blood-brain barrier is increased by cationizing the antibodies to provide cationized antibodies having an isoelectric point of between about 8.0 to 11Ø The increased rates of transport across the blood-brain barrier makes such cationized antibodies useful for both neurodiagnostic and neuropharmaceutical purposes. Methods for preparing such cationized antibodies are disclosed.
574859
Pardridge William M.
Schimmel Paul R.
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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