Caveolin-3 and in vitro culture of hepatitis c virus

Details Caveolin-3 and in vitro culture of hepatitis c virus Caveolin-3 and in vitro culture of hepatitis c virus

C - Chemistry, Metallurgy

12

N

C12N 7/02 (2006.01) A01K 67/027 (2006.01) C12Q 1/70 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2615558

Caveolin-3 has been identified as a cellular factor that associates with HCV protein El and E2, and is proposed as a cellular limiting factor. As an alternative possibility, caveolin-3 may act as a cellular receptor for HCV, acting alongside CD81. In either scenario, cells with increased expression of caveolin-3 will be better suited to the in vitro culture of HCV, and blocking the interaction between caveolin-3 and HCV proteins has therapeutic potential.

La cavéoline-3 a été identifiée comme étant un facteur cellulaire qui s'associe avec la protéine E1 et E2 du VHC et il a été proposé de l'utiliser en tant que facteur de limitation cellulaire. Selon une autre possibilité, la cavéoline-3 peut agir en tant que récepteur cellulaire pour le VHC, oeuvrant aux côtés de CD81. Dans les deux cas, l'expression accrue de la cavéoline-3 sera plus appropriée à la culture in vitro du VHC et le blocage de l'interaction entre la cavéoline-3 et les protéines VHC présente un potentiel thérapeutique.

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