Cb1 modulator compounds

Details Cb1 modulator compounds Cb1 modulator compounds

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61K 31/407 (2006.01) A61P 3/04 (2006.01) C07D 209/10 (2006.01) C07D 209/42 (2006.01) C07D 231/56 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2549396

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain- Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.

L'invention porte sur de nouveaux composés de formule structurelle (I). Ces composés sont utiles, en tant que modulateurs du récepteur Cannabinoïde-1 (CB1) dans le traitement, la prévention et la suppression de maladies médiées par le récepteur CB1. En tant que tels, ces composés sont utiles dans le traitement, la prévention et la suppression de psychoses, de pertes de mémoire, de troubles cognitifs, de la migraine, de neuropathies, de troubles neuro-inflammatoires (par exemple la sclérose en plaques, le syndrome Guillain-Barre et les séquelles inflammatoires de l'encéphalite virale), les accidents vasculaires cérébraux, les traumas crâniens, les troubles de l'anxiété, le stress, l'épilepsie, la maladie de Parkinson et la schizophrénie. Ces composés sont également utiles dans le traitement de troubles liés à l'abus de substances, notamment les opiacés, l'alcool ou la nicotine. Ils sont aussi utiles dans le traitement de l'obésité ou de troubles alimentaires associés à la prise excessive de nourriture et aux complications liées.

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