Cbp86, a sperm specific protein

Details Cbp86, a sperm specific protein Cbp86, a sperm specific protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2397901

The present invention relates to acidic (pI 4.0) 86 kDA isoforms of a novel, polymorphic, testis-specific protein designated calcium binding protein 86 (CBP86). This protein is tyrosine phosphorylated during in vitrocapacitation and bound calcium45 on 2-D gels, the latter effect abolished by dephosphorylation with alkaline phosphatase. CBP86 localizes to the principal piece of the human sperm flagellum in association with the fibrous sheath and is the first demonstration of a sperm protein that both oligomerizes and gains calcium binding capacity in a tyrosine phosphorylation dependent manner during capacitation.

L'invention concerne des isoformes acides (pI 4.0) de 86 kDa d'une nouvelle protéine polymorphe spécifique des testicules, appelée protéine de fixation de calcium 86(CBP86). Ladite protéine est phosphorylée sur tyrosine pendant la capacitation in vitro et fixe le calcium?45¿ sur des gels 2D, effet supprimé par déphosphorylation au moyen de phosphatase alcaline. La CBP86 se trouve sur la partie principale du flagelle de sperme humain combinée à la gaine fibreuse et est la première protéine de sperme qui oligomérise et qui acquiert une capacité de fixation du calcium en fonction de la phosphorylation sur tyrosine, pendant la capacitation.

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