C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 27/14 (2006.01) A61P 37/08 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2401491
A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
L'invention concerne un anticorps à recombinaison génique ou son fragment, réagissant spécifiquement avec le domaine extracellulaire du CCR4 humain ; un ADN codant ledit anticorps à recombinaison génique ou son fragment ; un procédé de production dudit anticorps à recombinaison génique ou de son fragment ; un procédé de détection immunologique de CCR4 ; un procédé de détection immunologique de cellules exprimant CCR4 à leur surface ; un procédé permettant de réduire ou d'éliminer les cellules exprimant CCR4 à leur surface ; et un procédé d'inhibition de la production de la cytokine Th2, chacun desdits procédés utilisant l'anticorps à recombinaison génique selon l'invention ou son fragment. L'invention concerne également des médicaments, des remèdes ou des diagnostics destinés aux maladies immunes à médiation Th2, ainsi que des médicaments ou diagnostics destinés au cancer du sang, chacun desdits produits renfermant ledit anticorps à recombinaison génique ou son fragment comme principe actif.
Furuya Akiko
Hanai Nobuo
Hosaka Emi
Nakamura Kazuyasu
Niwa Rinpei
Goudreau Gage Dubuc
Kyowa Hakko Kirin Co. Ltd.
Kyowa Hakko Kogyo Co. Ltd.
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