Ccr5 antagonist and dp-178 polypeptide for treating viral...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61K 31/00 (2006.01) A61K 31/45 (2006.01) A61K 31/4545 (2006.01) A61K 45/06 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2431919

This invention provides novel combination therapies comprising a CCR5 antagonist, or a pharmaceutically acceptable salt thereof, and a DP-178 polypeptide, or a pharmaceutically acceptable derivative thereof, for the treatment of HIV. The present combination permits a more tolerable treatment schedule by reducing the frequency of administration of a DP-178 polypeptide from twice daily subcutaneously to once daily or even just a few times per week.

L'invention concerne de nouvelles thérapies combinées contenant un antagoniste CCR5 ou un sel pharmaceutiquement acceptable de celui-ci et un polypeptide DP-178 ou un dérivé pharmaceutiquement acceptable de celui-ci afin de traiter le virus VIH. La présente combinaison permet une programmation de traitement plus tolérable en réduisant la fréquence d'administration d'un polypeptide DP-178, de deux fois par jour en sous-cutané à une fois par jour ou même jusqu'à quelques fois par semaine.

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