Ccr9 inhibitors and methods of use thereof

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 311/14 (2006.01) A61K 31/18 (2006.01) A61K 31/44 (2006.01) A61K 31/4965 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) C07C 311/15 (2006.01) C07D 213/02 (2006.01) C07D 213/50 (2006.01) C07D 213/65 (2006.01) C07D 213/70 (2006.01) C07D 213/71 (2006.01) C07D 213/75 (2006.01) C07D 213/76 (2006.01) C07D 213/80 (2006.01) C07D 213/89 (2006.01) C07D 237/06 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 239/42 (2006.01) C07D 239/69 (2006.01) C07D 333/34 (2006.01) C07D 333/62 (2006.01) C07D 405

Patent

CA 2485681

The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.

L'invention concerne des composés représentés par la formule structurale (I), qui sont capables de se lier avec les récepteurs CCR9 et de bloquer la liaison d'un ligand (p. ex. TECK) avec ces récepteurs. L'invention concerne également une méthode permettant d'inhiber la fonction du récepteur CCR9, et l'utilisation des composés représentés par la formule structurale (I) dans la recherche et dans des méthodes de traitement, de prévention et de diagnostic.

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