Cd10-activated prodrug compounds

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 1/16 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C12Q 1/37 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2450316

The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed.

Les composés selon l'invention sont des formes modifiées d'agents thérapeutiques. Un composé de promédicament type selon l'invention comprend un agent thérapeutique, un oligopeptide, une groupe de stabilisation et, éventuellement, un groupe de liaison. Ce promédicament est clivable par l'enzyme CD10. Sont également décrites des méthodes d'utilisation de ce promédicament et des techniques de conception d'un promédicament.

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