Cd147 binding molecules as therapeutics

Details Cd147 binding molecules as therapeutics Cd147 binding molecules as therapeutics

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2322749

In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.

La présente invention concerne la découverte selon laquelle la molécule CD147 exprimée sur certaines cellules, par exemple les cellules T, les cellules B, et/ou les monocytes, peut être utilisée pour traiter diverses maladies. En particulier, les anticorps qui se fixent à la CD147 et tuent ainsi les cellules susmentionnées, par exemple grâce à la fixation du complément, sont efficaces pour traiter certaines maladies, notamment la réaction du greffon contre l'hôte (GVHD), les maladies liées au rejet d'une greffe d'organe (y compris, sans limitation, la transplantation rénale, la transplantation oculaire, et d'autres), les cancers (y compris, sans limitation, les cancers du sang (c'est-à-dire les leucémies et les lymphomes), les cancers du pancréas, et d'autres), les maladies auto-immunes, les maladies inflammatoires, et d'autres.

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