A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2294138
Methods and compositions for attenuating or mitigating; suppressing; preventing; delaying onset of; or, reversing exogenous protein inhibitor syndromes, exemplified by clotting factor (e.g., Factor VIII) inhibitor syndromes. The described methods use a CD40:CD154 binding interruptor, such as CD154 blocking agent, to attenuate or ameliorate counter-adaptive, bioinhibitory humoral immunity directed against an exogenous protein of therapeutic value.
Cette invention se rapporte à des procédés et à des compositions pour atténuer ou affaiblir, supprimer, prévenir ou retarder l'apparition de syndromes inhibiteurs de protéines exogènes ou pour inverser de tels syndromes, dont des exemples sont fournis par les syndromes inhibiteurs des facteurs de coagulation (tels que le facteur VIII). Ces procédés utilisent un interrupteur de liaison CD40:CD154, tel qu'un agent de blocage de cellules CD154, pour atténuer ou améliorer l'immunité humorale bio-inhibitrice contre-adaptative, dirigée contre une protéine exogène de valeur thérapeutique.
Biogen Inc.
Biogen Idec Ma Inc.
Smart & Biggar
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