C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2611814
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD 19 with high affinity. Nucleic acid molecules encoding such CD 19 antibodies, expression vectors, host cells and methods for expressing the CD 19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD 19 antibodies are also provided. Methods for detecting CD 19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
La présente invention concerne des anticorps monoclonaux isolés, et plus particulièrement des anticorps monoclonaux humains se liant avec une affinité élevée spécifiquement au CD19. L'invention concerne également des molécules d'acide nucléique codant de tels anticorps CD19, des vecteurs d'expression, des cellules hôtes, et des procédés d'expression des anticorps CD19. L'invention concerne aussi des immunoconjugués, des molécules bi-spécifiques et des compositions pharmaceutiques comprenant les anticorps CD19. L'invention concerne enfin des procédés permettant de détecter le CD19, ainsi que des procédés destinés au traitement de diverses malignités des lymphocytes B, y-compris les lymphomes non Hodgkinniens.
Bell Alasdair Fraser
Cardarelli Josephine M.
Chen Sharline
Huang Haichun
King David John
Medarex Inc.
Smart & Biggar
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