A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2525139
The present invention relates to CD20 binding molecules and nucleic acid sequences encoding CD20 binding molecules. In particular, the present invention relates to CD20 binding molecules with a high binding affinity, and a low dissociation rate, with regard to human CD20. Preferably, the CD20 binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
L'invention concerne des molécules de liaison de CD20 et des séquences d'acide nucléique codant les molécules de liaison de CD20. En particulier, l'invention concerne des molécules de liaison de CD20 comprenant une affinité de liaison élevée, et un taux de dissociation faible, par rapport aux CD20 humains. De préférence les molécules de liaison de CD20 de l'invention comprennent des régions variable à chaînes légères et/ou lourdes avec des infrastructures complètement humaines (par exemple des infrastructures humaines germinales).
Allan Barrett W.
Davies Julian
Marquis David M.
Ondek Brian
Watkins Jeffry D.
Applied Molecular Evolution Inc.
Gowling Lafleur Henderson Llp
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