Cd20-specific antibodies and methods of employing same

Details Cd20-specific antibodies and methods of employing same Cd20-specific antibodies and methods of employing same

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2525251

The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical compositions comprising the same. The invention further provides methods of using the monoclonal antibodies, antigen-binding fragments, and pharmaceutical compositions, for example, in methods of depleting B cells or in treating B cell disorders. Also provided are cells, nucleic acids and methods for producing the monoclonal antibodies.

L'invention concerne des anticorps monoclonaux et leurs fragments de liaison à l'antigène qui se lient spécifiquement à CD20 ainsi que des compositions pharmaceutiques comprenant lesdits éléments. L'invention concerne également des méthodes d'utilisation desdits anticorps monoclonaux, fragments de liaison à l'antigène et compositions pharmaceutiques, par exemple, dans des méthodes de déplétion des lymphocytes B ou dans le traitement des troubles des lymphocytes B. L'invention concerne également des cellules, des acides nucléiques et des méthodes de production desdits anticorps monoclonaux.

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