Cd3 specific recombinant antibody

Details Cd3 specific recombinant antibody Cd3 specific recombinant antibody

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2050479

A recombinant antibody molecule comprises antigen binding regions derived from the heavy and/or light chain variable regions of a donor anti-CD3 antibody, e.g. OKT3, and has anti-CD3 binding specificity, preferably of affinity similar to that of OKT3. The recombinant antibody is preferably a humanised antibody and may be a chimeric or CDR-grafted antibody. A proto- col is disclosed for preparing CDR-grafted humanised antibodies in which, in addition to the CDRs non-human antibody resi- dues are preferably used at positions 23, 24, 49, 71, 73 and 78 of the heavy chain variable region and at positions 46, 48, 58 and 71 of the light chain variable region. The recombinant, especially the humanised, anti-CD3 antibodies may be used for in vivo ther- apy or diagnosis.

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