Cd33-specific single-chain immunotoxin and method of use

Details Cd33-specific single-chain immunotoxin and method of use Cd33-specific single-chain immunotoxin and method of use

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 39/395 (2006.01) A61P 35/02 (2006.01) C07K 16/28 (2006.01) C07K 14/21 (2006.01)

Patent

CA 2616898

A single-chain immunotoxin composition and method of treatment with the composition is disclosed. Preferably, the immunotoxin is comprised of a CD33- specific single chain Fv antibody fragment and a genetically engineered variant of Pseudomonas Exotoxin A (ETA). A preferred engineered Exotoxin A is referred to ETA' and may includes a KDEL peptide at its C-terminus, a cellular peptide mediating improved retrograde transport to the endoplasmic reticulum (ER). The immunotoxin compound may be formulated with a carrier and administered into patients where the antibody portion binds to CD33-positive cells and kills those cells to provide an effective treatment for diseases such as human myeloid leukemia.

L'invention concerne une composition d'immunotoxine à chaîne simple et un procédé de traitement au moyen de cette composition. De préférence, l'immunotoxine contient un fragment d'anticorps Fv à chaîne simple CD33 spécifique et un variant génétiquement modifié d'exotoxine de Pseudomonas A (ETA). Une exotoxine A modifiée préférée est nommée ETA' et peut contenir un peptide KDEL au niveau de son terminus C, un peptide cellulaire induisant un transport rétrograde amélioré au réticulum endoplasmique (ER). Le composé d'immunotoxine peut être formulé au moyen d'un véhicule et administré chez un patient dont la partie d'anticorps se lie aux cellules CD33 positives et tue ces cellules afin de fournir un traitement efficace contre les maladies telles que la leucémie myéloïde humaine.

Affiliated with

Also associated with

Rating

Cd33-specific single-chain immunotoxin and method of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cd33-specific single-chain immunotoxin and method of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cd33-specific single-chain immunotoxin and method of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2072997