Cd36 as a heat shock protein receptor and uses thereof

Details Cd36 as a heat shock protein receptor and uses thereof Cd36 as a heat shock protein receptor and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C12N 9/00 (2006.01) C12N 9/48 (2006.01) C12N 15/85 (2006.01) C12P 11/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2424932

The present invention relates to the use of CD36 ("CD36") receptor as a heat shock protein receptor, cells that express CD36 bound to an HSP, and antibodies and other molecules that bind CD36-HSP complex. The invention also relates to screening assays to identify compounds that interact with CD36, and modulate the interaction of CD36 with its ligand, such as HSPs, and methods for using compositions comprising CD36-receptor sequences for the diagnosis and treatment of immune disorders, proliferative disorders, and infectious diseases.

L'invention concerne l'utilisation du récepteur CD36 ("CD36") en tant que récepteur de la protéine de choc thermique, les cellules qui expriment CD36 lié à une protéine de choc thermique (HSP) ainsi que des anticorps et d'autres molécules qui se lient à un complexe CD36-HSP. L'invention concerne également des essais de criblage servant à identifier des composés qui interagissent avec CD36 et qui modulent l'interaction de CD36 avec son ligand, notamment des HSP, ainsi que des méthodes permettant d'utiliser des compositions comprenant des séquences du récepteur CD36 pour le diagnostic et le traitement des affections immunitaires, des affections prolifératives et des maladies infectieuses.

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