C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 31/4184 (2006.01) A61K 39/395 (2006.01) A61P 35/02 (2006.01) C12N 15/02 (2006.01)
Patent
CA 2719924
The present disclosure provides a humanized anti-CD37 small modular immunopharmaceutical (SMIP) molecule, as well as synergistic combination therapies of CD37-specific binding molecules (such as anti-CD37 SMIP proteins or antibodies) with bifunctional chemotherapeutics (such as bendamustine) that can be administered concurrently or sequentially, for use in treating or preventing B cell related autoimmune, inflammatory, or hyperproliferative diseases.
L'invention concerne une petite cellule immunopharmaceutique modulaire (SMIP) anti-CD37 humanisée, de même que des thérapies combinatoires synergistiques de molécules de liaison spécifique à CD37 (comme des protéines ou anticorps SMIP anti-CD37) avec des produits de chimiothérapie bifonctionnels (comme de la Bendamustine) qui peuvent être administrés en même temps ou séquentiellement, pour une utilisation dans le traitement ou la prévention de maladies auto-immunes, inflammatoires ou hyperprolifératives en rapport avec la cellule B.
Brady William
Cerveny Charles G.
Hayden-Ledbetter Martha Susan
Ledbetter Jeffrey A.
Morales Cecile
Emergent Product Development Seattle Llc
Smart & Biggar
Trubion Pharmaceuticals Inc.
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