Cd40-binding apc-activating molecules

Details Cd40-binding apc-activating molecules Cd40-binding apc-activating molecules

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2398998

Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells ("APCs"), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.

La présente invention concerne des molécules anti-CD40 agonistes, incluant des anticorps monoclonaux, qui peuvent se lier à des cellules de présentation d'antigène (APC) humaines professionnelles et non professionnelles et les stimuler, renforcer l'effet stimulant du CD40L sur les cellules positives CD40 et/ou induire une maturation phénotypique des cellules dendritiques dérivées de monocytes. L'invention concerne plus particulièrement divers tels anticorps monoclonaux, ainsi que des lignées cellulaires les produisant, déposés auprès de la "American Type Culture Collection".

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