C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2672916
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to CD44, and that function to inhibit CD44. The invention also relates to heavy and light chain immunoglobulins derived from human CD44 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human CD44 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions or medicaments for treatment.
L'invention concerne des anticorps comprenant des anticorps humains et des parties de ceux-ci se liant à des antigènes, qui se lient à CD44, et qui servent à inhiber CD44. L'invention concerne également des immunoglobulines à chaîne lourde et à chaîne légère dérivées d'anticorps anti-CD44 humains et des molécules d'acide nucléique codant de telles immunoglobulines. L'invention concerne également des procédés de fabrication d'anticorps anti-CD44 humains, des compositions comprenant ces anticorps et des procédés d'utilisation thérapeutiques de ces anticorps, de ces compositions ou de médicaments associés.
Badkar Advait V.
Bedian Vahe
Huang Haichun
Meaddough Erika
Srinivasan Mohan
Bristol-Myers Squibb Company
Medarex Inc.
Pfizer Inc.
Smart & Biggar
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