A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 38/39 (2006.01) C07K 14/705 (2006.01) C12Q 1/02 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2179391
Disclosed are methods of treating arteriosclerosis or vascular restenosis by inhibiting CD44-mediated smooth muscle migration or proliferation as well as methods of screening for the identification of compounds capable of inhibiting the expression of CD44, inhibiting the CD44-mediated migration of smooth muscle cells, and inhibiting the CD44-mediated proliferation of smooth muscle cells.
L'invention se rapporte à des procédés de traitement de l'artériosclérose ou de la resténose vasculaire qui consistent à inhiber la migration ou la prolifération des cellules des muscles lisses induite par CD44, ainsi qu'à des procédés de criblage afin d'identifier des composés capables d'inhiber l'expression de CD44, d'inhiber la migration des cellules des muscles lisses induite par CD44, et d'inhiber la prolifération des cellules des muscles lisses induite par CD44.
Haber Edgar
He Qi
Kirby Eades Gale Baker
President And Fellows Of Harvard College
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