Cd44 splice variants in neurodegenerative diseases

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2692861

There is provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression of ribonucleic acid (RNA) encoded by a nucleic acid, wherein the nucleic acid is selected from a group that includes a contiguous nucleotide sequence being at least 90% homologous to at least 20 nucleotides of: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, or any combination thereof. There is further provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression and/or activity of a polypeptide, wherein the sequence of the polypeptide is selected from a group that includes a contiguous amino acid sequence being at least 90% homologous to at least 10 amino acid of: SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, or any combination thereof.

La présente invention concerne un procédé de traitement ou de prévention d'une maladie neurodégénérative, qui consiste à administrer une composition contenant un réactif capable de moduler l'expression de l'acide ribonucléique (ARN) codé par un acide nucléique, l'acide nucléique étant sélectionné parmi un groupe qui inclut une séquence nucléotidique contiguë au moins homologue à 90 % à au moins 20 nucléotides de séquence : SEQ ID NO : 1, SEQ ID NO : 3, SEQ ID NO : 5, SEQ ID NO : 7, ou n'importe laquelle de leurs combinaisons. L'invention concerne en outre un procédé de traitement ou de prévention d'une maladie neurodégénérative, qui consiste à administrer une composition contenant un réactif capable de moduler l'expression et/ou l'activité d'un polypeptide, la séquence du polypeptide étant sélectionnée parmi un groupe comprenant une séquence d'acides aminés contiguë au moins homologue à 90 % à au moins 10 acides aminés de séquence : SEQ ID NO : 2, SEQ ID NO : 4, SEQ ID NO : 6, SEQ ID NO : 8, ou n'importe laquelle de leurs combinaisons.

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