A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/728 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2560200
The present invention relates to CD44 binding molecules, preferably anti-CD44 antibodies, and their use in methods for the prevention or reduction of ischemia-reperfusion injury in e.g. solid organ transplantation or in patients in shock. The invention further relates to methods wherein levels of soluble CD44 are determined in e.g. serum or urine as a prognostic factor for the risk of organ rejection.
La présente invention concerne des molécules de liaison CD44, de préférence des anticorps anti-CD44, ainsi que leur utilisation dans des méthodes de prévention et de réduction des lésions par ischémie-reperfusion à la suite,notamment, d'une transplantation d'un organe solide ou chez des patients en état de choc. L'invention concerne en outre des méthodes consistant à déterminer des niveaux de CD44 solubles, par exemple dans un sérum ou de l'urine, en tant que facteur de pronostic quant à un risque de rejet d'organes.
Florquin Sandrine
Rouschop Kasper Mathias Antoon
Academisch Ziekenhuis Bij de Universiteit Van Amsterdam
Gowling Lafleur Henderson Llp
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