C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 31/12 (2006.01) A61P 37/04 (2006.01) C07K 14/705 (2006.01) C07K 16/08 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) C07K 14/065 (2006.01)
Patent
CA 2652570
Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.
La présente invention concerne des polypeptides de fusion qui contiennent un domaine CD47 extracellulaire, ou un variant de celui-ci, fusionné avec un polypeptide Fc. Les polypeptides de fusion sont utiles pour le traitement d'une maladie ou d'un trouble immunologique chez un sujet selon les procédés décrits dans ce document. Les polypeptides de fusion sont capables de supprimer la faculté d'immuno-réponse d'une cellule immune et d'inhiber la production de cytokines proinflammatoires, y compris l'inhibition de la production de cytokines induite par le complexe immun.
Kaykas Ajamete
Probst Peter
Smith Craig A.
Wiley Steven
Smart & Biggar
Viral Logic Systems Technology Corp.
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