Cd53 cell surface antigen and use thereof

Details Cd53 cell surface antigen and use thereof Cd53 cell surface antigen and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2087272

A simple and highly efficient method for cloning cDNAs from mammalian expression libraries based on transient expression in mammalian host cells has been discovered. Novel expression vectors allowing highly efficient construction of mammalian cDNA libraries are disclosed. The cloning method of the invention which has been used to clone genes for cell surface antigens of human lymphocytes, has general application in gene cloning. Cell surface antigens cloned according to the present invention have been purified, and the nucleotide and amino acid sequences determined. These antigens have diagnostic and therapeutic utility in immune-mediated infections in mammals, including humans.

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