C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2220098
The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell types. The invention further relates to methods of inhibiting the interaction of CD6 and the CD6 ligand, and to methods of screening compounds for their ability to inhibit that interaction.
La présente invention se rapporte de manière générale à CD6 et plus particulièrement au ligand CD6 présent à la surface des cellules épithéliales thymiques, de monocytes, des lymphocytes thymo-dépendants activés et d'une variété d'autres cellules. L'invention concerne aussi les procédés permettant d'inhiber l'interaction de CD6 et du ligand CD6, ainsi que des techniques de criblage des composés visant à mettre en évidence leur capacité à inhiber cette interaction.
Aruffo Alejandro
Bowen Michael A.
Haynes Barton F.
Marquardt Hans
Patel Dhavalkumar
Bristol-Myers Squibb Company
Duke University
Gowling Lafleur Henderson Llp
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