Cd8 binding domain peptides

Details Cd8 binding domain peptides Cd8 binding domain peptides

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 38/03 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 39/395 (2006.01) C07K 4/12 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2122266

2122266 9308817 PCTABS00021 The present invention provides compositions comprising a peptide having between about 7 and about 20 amino acid residues, the peptide being capable of binding a CD8 molecule on a cytolytic T lymphocyte (CTL) precursor and inhibiting differentiation of the CTL precursor to mature CTL. The peptides have amino acid sequences substantially homologous to a sequence in an .alpha.3 domain of a human Class I MHC molecule. The sequence from the .alpha.3 domain is preferably between residue (220) and residue (235). The peptides typically comprise the sequence DQTQDTE (SEQ. ID No. 1) or EDQTQDTELVETRP (SEQ. ID No. 2).

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