Cd86 antagonist multi-target binding proteins

Details Cd86 antagonist multi-target binding proteins Cd86 antagonist multi-target binding proteins

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01)

Patent

CA 2739460

This disclosure provides a multi-specific fusion protein composed of a CD86 antagonist binding domain and another binding domain that is an IL-10 agonist, an HLA-G agonist, an HGF agonist, an IL-35 agonist, a PD-1 agonist, a BTLA agonist, a LIGHT antagonist, a GITRL antagonist or a CD40 antagonist. The multi-specific fusion protein may also include an intervening domain that separates the other domains. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.

La présente invention concerne une protéine de fusion multispécifique composée d'un domaine de liaison antagoniste de CD86 et d'un autre domaine de liaison qui est un agoniste d'IL-10, un agoniste de HLA-G, un agoniste de HGF, un agoniste d'IL-35, un agoniste de PD-1, un agoniste de BTLA, un antagoniste de LIGHT, un antagoniste de GITRL ou un antagoniste de CD40. La protéine de fusion multispécifique peut également comprendre un domaine intermédiaire qui sépare les autres domaines. L'invention concerne également des polynucléotides codant pour les protéines de fusion multispécifiques, des compositions de ces protéines de fusion, et des méthodes d'utilisation des protéines de fusion multispécifiques et des compositions.

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