Cd95 regulatory gene sequences and transcription factors

Details Cd95 regulatory gene sequences and transcription factors Cd95 regulatory gene sequences and transcription factors

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2263824

Regulatory DNA sequences that silence and enhance transcription of coding portions of the CD95 gene, which is instrumental in apoptosis, are disclosed. Proteinaceous transcription factors that bind to the silencer and enhancer regulatory sequences are also disclosed and are useful for modulating the expression of CD95 or other proteins. Methods for regulating apoptosis have therapeutic and prophylactic applications for a variety of disorders, including cancer, viral and retroviral infections, neurodegenerative disorders, immune system dysfunction, and other disorders.

Cette invention concerne des séquences d'ADN régulatrices permettant d'effacer et d'accroître la transcription des parties de codage du gène CD95, cette dernière étant instrumentale lors de l'apoptose. Cette invention concerne également des facteurs de transcription protéiniques qui se lient aux séquences régulatrices d'effacement et d'accroissement, et qui sont utiles dans la modulation de l'expression de CD95 ou d'autres protéines. Cette invention concerne enfin des procédés de régulation de l'apoptose, lesquels peuvent être utilisés de manière thérapeutique ou prophylactique dans le traitement d'affections diverses, y compris le cancer, les infections virales et rétrovirales, les troubles neurodégénératifs, les dysfonctionnements du système immunitaire ou d'autres troubles.

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