Cdk2 protein and cdk2 protein complexes

Details Cdk2 protein and cdk2 protein complexes Cdk2 protein and cdk2 protein complexes

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 1/19 (2006.01) C12N 15/62 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2309390

The present invention discloses complexes of the CDK2 protein with proteins identified as interacting with the CDK2 protein (CDK2 protein-IPs) by a modified, improved yeast two hybrid assay system. The proteins which were identified to interact with the CDK2 protein, and thus form complexes, included: cyclin I, ERH, hsReq*-1 and hsReq*-2, as well as derivatives, fragments analogs and homologs thereof. The invention also provides nucleic acids encoding the hsReq*-1 and hsReq*-2 nucleotide sequences, and proteins and derivatives, fragments and analogs thereof. Methodologies of screening these aforementioned complexes for efficacy in treating and/or preventing various diseases and disorders, particularly neoplasia and atherosclerosis, are also disclosed herein.

L'invention concerne des complexes constitués de protéine CDK2 et de protéines identifiées comme interagissant avec ladite protéine CDK2 (IP-protéine CDK2) par un système d'analyse amélioré à deux hybrides de levure. Les protéines ayant été identifiées comme interagissant avec la protéine CDK2, et donc formant des complexes avec elle, sont la cycline I, ERH, hsReq*-1 et hsReq*-2, ainsi que leurs dérivés, fragments, analogues et homologues. L'invention concerne également des acides nucléiques codant pour les séquences nucléotidiques hsReq*-1 et hsReq*-2, ainsi que des protéines et leurs dérivés, fragments et analogues. Elle concerne aussi des méthodologies permettant de cribler les complexes ci-dessus afin de déterminer leur efficacité pour traiter et/ou prévenir des maladies et des troubles divers, notamment les néoplasies et l'athérosclérose.

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