Cdki pathway inhibitors as selective inhibitors of tumor...

Details Cdki pathway inhibitors as selective inhibitors of tumor... Cdki pathway inhibitors as selective inhibitors of tumor...

A - Human Necessities

61

K

A61K 31/4045 (2006.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2652339

The invention provides new methods for inhibiting the CDKI pathway and specifically inhibiting tumor cell growth. The invention further provides new and specific inhibitors of tumor cell growth, as well as means for discovery of additional such inhibitors. The present inventors have surprisingly discovered that Cyclin-Dependent Kinase 3 (CDK3) is specifically required for tumor cell growth, in contrast to other members of the CDK family.

Cette invention concerne des nouvelles méthodes pour inhiber la voie des CDKI et plus spécifiquement pour inhiber la croissance des cellules tumorales. Cette invention concerne également des nouveaux inhibiteurs de la croissance des cellules tumorales spécifiques, ainsi que des moyens permettant de découvrir d'autres inhibiteurs identiques. Par rapport aux autres membres de la famille des CDK, la kinase 3 dépendante des cyclines 3 (CDK3) s'est révélée être plus particulièrement utile pour la croissance des cellules tumorales.

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