Cdkl1 as modifier of branching morphogenesis and methods of use

Details Cdkl1 as modifier of branching morphogenesis and methods of use Cdkl1 as modifier of branching morphogenesis and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/715 (2006.01) C12N 9/12 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2502685

Human CDKL1 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of CDKL1 are provided.

Selon l'invention, des gènes humains de CDKL1 sont identifiés en tant que modulateurs de la morphogenèse de branchement et constituent ainsi des cibles thérapeutiques pour des troubles associés à une fonction défectueuse de la morphogenèse de branchement. L'invention concerne des procédés d'identification de modulateurs de la morphogenèse de branchement, lesquels consistent à cribler des agents qui modulent l'activité de CDKL1.

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