C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2220855
HDPBI30 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HDPBI30 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infraction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
On divulgue des polypeptides et polynucléotides HDPBI30 et des méthodes pour produire ces polypeptides par les techniques de recombinaison. On divulgue également des méthodes pour utiliser les polypeptides et polynucléotides HDPBI30 dans la conception de protocoles pour le traitement des infections comme les infections bactériennes, fongiques, protozoaires et virales, et particulièrement les infections causées par le VIH-1 ou le VIH-2; la douleur; les cancers; l'anorexie; la boulimie; l'asthme; la maladie de Parkinson; l'insuffisance cardiaque aiguë; l'hypotension; l'hypertension; la rétention urinaire; l'ostéoporose; l'angine de poitrine; l'infarctus du myocarde; les ulcères; l'asthme; les allergies; l'adénome prostatique; et les troubles psychotiques et neurologiques, dont l'anxiété, la schizophrénie, la maladie affective bipolaire, le délire, la démence, la déficience mentale grave et les dyskinésies, comme la chorée de Huntington ou le syndrome de Gilles de La Tourette, entre autres, et les épreuves diagnostiques pour ces affections.
Sathe Ganesh M.
Van Horn Stephanie
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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