C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2219960
HE8CS41 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HE8CS41 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension, urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
Il s'agit de polynucléotides et polypeptides HE8CS41, de méthodes de recombinaison permettant d'obtenir ces polypeptides et de méthodes permettant d'utiliser les polynucléotides et polypeptides HE8CS41 pour la conception de protocoles visant le traitement des infections entre autres dues à des bactéries, à des champignons, à des protozoaires et à des virus (aux virus HIV-1 et HIV-2 en particulier), de la douleur, du cancer, de l'anorexie, de la boulimie, de l'asthme, de la maladie de Parkinson, de l'insuffisance cardiaque aiguë, de l'hypotension, de l'hypertension, de la rétention d'urine, de l'ostéoporose, de l'angine de poitrine, de l'infarctus du myocarde, des ulcères, des allergies, de l'hypertrophie prostatique bénigne et de divers troubles psychotiques et neurologiques tels que l'anxiété, la schizophrénie, le délire maniaco-dépressif, la démence, le retard mental grave et les dyskinésies, dont les maladies de Huntington et de Gilles de La Tourette, ainsi que d'épreuves diagnostiques pour ces affections.
Bergsma Derk Jon
Mao Joyce Yue
Sathe Ganesh M.
Van Horn Stephanie
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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