Cdna clones encoding human g protein .gamma. subunits

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2221783

Nucleic acid molecules encoding human .gamma.2, .gamma.3, .gamma.4, .gamma.5, .gamma.7, .gamma.10 and .gamma.11 subunits are provided. Subunits polypeptides are also provided. In addition, methods of detecting mutated forms of human .gamma. subunit and altered levels of human .gamma. subunit are provided. Methods of identifying antagonists and agonists of the interaction of a .beta..gamma. ligand with its receptor are also provided.

L'invention porte sur des molécules d'acide nucléique codant des sous-unités humaines .gamma.¿2?, .gamma.¿3?, .gamma.¿4?, .gamma.¿5?, .gamma.¿7?, .gamma.¿10? et .gamma.¿11? ainsi que sur des polypeptides de sous-unités. Elle concerne, de surcroît, des procédés permettant de déceler des formes mutées de la sous-unité .gamma. humaine ainsi que des niveaux modifiés de la sous-unité .gamma. humaine. L'invention concerne également des procédés permettant d'identifier des antagonistes et des agonistes de l'interaction d'un ligand .beta..gamma. avec son récepteur.

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