C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.22, 195/1.
C12N 1/20 (2006.01) A61K 38/37 (2006.01) C07K 14/755 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01)
Patent
CA 1341095
Full length human von Willebrand factor (vWF) cDNA was assembled from partial, overlapping vWF cDNAs. This cDNA construct includes an "open" reading frame of 2,813 amino-acid residues, apparently representing a (pre)-pro-sequence of 763 and mature vWF of 2,050 amino acids. Both the pro- sequence and mature vWF harbor an arg-gly-asp ("R-G-D") sequence which has been implicated in cell attachment functions. It is assumed that the pro-sequence is equivalent to von Willebrand Antigen II (vW AgII). The (glyco)-proteins prepared by cultivation of microorganisms or other hosts like animal or human cells containing a plasmide or phage with said cDNA-coding may be used in pharmaceutical compositions intended for administration to patients with the von Willebrand's disease.
505491
Diergaarde Paul Johan
Hart Margaretha Hendrika Louise
Pannekoek Hans
Verweij Cornelis Lammert
Baxter Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Stichting Vrienden Van de Stichting Dr. Karl Landsteiner
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