Cdna corresponding to the antigenome of nonsegmented...

Details Cdna corresponding to the antigenome of nonsegmented... Cdna corresponding to the antigenome of nonsegmented...

C - Chemistry, Metallurgy

12

N

C12N 7/02 (2006.01) A61K 31/7088 (2006.01) A61K 39/155 (2006.01) A61K 48/00 (2006.01) C07K 14/12 (2006.01) C07K 14/145 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2228956

The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.

L'invention concerne, d'une manière générale, une méthodologie pour la génération de virus ARN à souche négative et non segmentés (Pringle 1991) à partir d'acide désoxyribonucléique cloné (ADNc). Ces virus récupérés peuvent être utilisés comme vaccins, ou comme plasmides dans des applications de thérapies géniques somatiques. L'invention porte également sur des molécules d'ADNc pouvant être utilisées comme outils dans cette méthodologie et sur des lignées de cellules auxiliaires permettant la récupération directe desdits virus. Le virus de la rougeole est utilisé comme modèle pour d'autres représentants de Mononegavirales, en particulier de la famille des paramxxoviridae.

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