C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/527 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2086411
2086411 9201041 PCTABS00010 Molecular cloning and expression of the D1 dopamine receptor protein is linked to the activation of adenylyl cyclase activity. By constructing cell lines that express the D1 receptor, the affinities and efficacies of agonist and antagonist drugs with the receptor can be assessed. A recombinant DNA construct includes a vector and a DNA fragment encoding the D1 receptor. A host cell is transformed with a recombinant DNA construct, so that the DNA fragment is expressed and the D1 receptor is produced. Suitable expression systems include eukaryotic and procaryotic cells, especially mammalian cells such as rat or human. Additionally, for diagnostic purposes, antibodies to the D1 receptor can be prepared by producing all or a portion of the receptor protein and injecting these into various types of mammals. Using the resulting antibodies, expression of the D1 receptor cDNA in cells can be measured.
Mahan Lawrence C.
Mcvittie Loris D.
Monsma Frederick Jr.
Sibley David R.
Gowling Lafleur Henderson Llp
Mahan Lawrence C.
Mcvittie Loris D.
Monsma Frederick Jr.
Sibley David R.
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