C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A01K 67/027 (2006.01) A61K 38/44 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 9/02 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2366058
The present invention relates to the cloning and sequencing of the cDNA molecules of three members of a gene family encoding three human fatty acid desaturases, fatty acid desaturase-1 (FADS1), fatty acid desaturase-2 (FADS2) and fatty acid desaturase-3 (FADS3). The invention also relates to diagnostic methods of screening for and detection of FADS1, FADS2, FADS3 and gene therapy utilizing recombinant DNA as well as the generation of animal models (knock- in, knock-out, transgenic animals), anti-FADS1, anti-FADS2, anti-FADS3 antibodies and use in screenings for modulating drugs.
La présente invention concerne le clonage et le séquençage des molécules d'ADNc de trois membres d'une famille de gènes codant pour trois désaturases d'acide gras humaines, la désaturase-1 d'acide gras (FADS1), la désaturase-2 d'acide gras (FADS2) et la désaturase-3 d'acide gras (FADS3). L'invention concerne également des techniques de diagnostic permettant de cribler et de détecter FADS1, FADS2, FADS3; une thérapie génique utilisant de l'ADN recombinant; la génération de modèles animaux (animaux knock-in, animaux knock-out, animaux transgéniques); ainsi que des anticorps anti-FADS1, anti-FADS2 et anti-FADS3 et leur utilisation dans le criblage de médicaments modulateurs.
Marquardt Andreas
Weber Bernhard H. F.
Goudreau Gage Dubuc
Lynkeus Biotech Gmbh
Multigene Biotech Gmbh
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