Cdnas coding for human proteins having transmembrane domains

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2305848

The invention provides cDNAs coding for human proteins having transmembrane domains and eucaryotic cells expressing said cDNAs. The cDNAs of the invention can be utilized as probes for the gene diagnosis and gene sources for the gene therapy. Furthermore, the cDNAs can be utilized for large-scale expression of said proteins. Cells, wherein these membrane protein genes are introduced and membrane proteins are expressed in large amounts, can be utilized for detection of the corresponding ligands, screening of novel low-molecular pharmaceuticals, and so on.

L'invention se rapporte à de l'ADNc codant pour des protéines humaines possédant des domaines transmembranaires et à des cellules eucaryotes exprimant ledit ADNc. L'ADNc en question peut être utilisé en tant que sonde moléculaire pour le diagnostic génétique et en tant que sources de gènes pour la thérapie génique. Il peut en outre être utilisé pour l'expression à grande échelle desdites protéines. Des cellules, dans lesquelles on introduit ces gènes de protéines membranaires et dans lesquelles les protéines membranaires sont exprimées en grandes quantités, peuvent servir à la détection des ligands correspondants, à l'analyse de nouveaux produits pharmaceutiques à faible poids moléculaire, etc.

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