Cdnas coding for the subunit of the high-affinity receptor...

Details Cdnas coding for the subunit of the high-affinity receptor... Cdnas coding for the subunit of the high-affinity receptor...

C - Chemistry, Metallurgy

12

N

530/13, 195/1.22

C12N 15/12 (2006.01) C07K 14/735 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2000878

Disclosed herein is the isolation and sequencing of the cDNA coding for the ~ subunit of the high-affinity receptor for immunoglobulin E (IgE) on mast cells and basophils. Also disclosed is the expression of the receptor when the cDNA for its .alpha., .beta. and ~ subunits are simultaneously contransfected. This success in expression of IgE binding permits detailed analysis of the IgE-receptor interaction and thus enables the development of therapeutically effective inhibitors.

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