Cell ablation using trans-splicing ribozymes

Details Cell ablation using trans-splicing ribozymes Cell ablation using trans-splicing ribozymes

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01H 5/00 (2006.01) A01N 57/16 (2006.01) A61K 31/70 (2006.01) C07H 21/02 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12N 15/66 (2006.01) C12N 15/82 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) C12N 15/90 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2100579

2100579 9213089 PCTABS00014 The design of new ribozymes capable of self-catalyzed trans-splicing which are based upon the catalytic core of a Group I intron are described. Using this design, it is possible to construct ribozymes capable of efficiently splicing a new 3' exon sequence into any chosen target RNA sequence in a highly precise manner. A method of cell ablation is also described that provides a toxic product to a host cell in vivo in a targetted, regulated manner utilizing novel trans-splicing ribozymes of the invention. Inactive pro-ribozyme forms are also described.

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